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Progress in the calculation of DNA in Shanghai

Date:2015-12-10 13:06:13   Click:0

Recently, the Chinese Academy of Sciences, Shanghai Institute of Applied Physics, Institute of physics and biology, Aarhus University, cooperation with the, based on the mathematical operation of the DNA nano structure has made new progress, the establishment of a combination of principles based on the principle of the DNA calculator. The results were published in the journal Nature & Communication (Communications Nature, 6, 2015, 10089), the Journal reported (release Press). 
DNA molecules with a strong sequence of programmable and accurate molecular recognition ability, is considered to be the development of the next generation of biological computers of the ideal material. In 1994, Turing Award winner Leonard Adleman was first proposed by Professor DNA computing, the parallel computing ability of DNA molecules show strong. However, there are some problems, such as input and output, signal crosstalk, low efficiency, and lack of intuitive output mode, and the operation process and results are often difficult to interpret, which limits the development of DNA computing field. 
Shanghai Institute of materials, such as Liu Huajie, Fan Chunhai and other researchers and professors Gothelf Kurt cooperation, based on the principle of the establishment of a similar combination of "look up table" of the new DNA computing model, significantly improve the efficiency of DNA computing. In computer science, it can be avoided by using a look-up table to avoid the multilevel logic operation in complex operation process. The lookup table built by DNA has the ability to accommodate a large variable. For example, the DNA sequence of 8 bases has a 48=65536 type of encoding. Using DNA powerful parallel computing ability, we can efficiently access the lookup table. The example of the research is to demonstrate the mode of multiplication operation, and use the visual digital output form of similar electronic calculator. The results of the calculation can be interpreted in the multi - scale display of the digital results. This DNA computing model has the characteristics of modular design, which is expected to be a prototype DNA computer, which is suitable for ordinary users.